NanoBiomechanics Lab | Publications

Publications

Link to Complete Publications List – NCBI.

G. Tartaglia, I. Fuentes, N. Patel, A. Varughese, L. E. Israel, P. H. Park, M. H. Alexander, S. Poojan, Q. Cao, B. Solomon, Z. M. Padron, J. A. Dyer, J. E. Mellerio, J. A. McGrath, F. Palisson, J. Salas-Alanis, L. Han, and A. P. South. Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa. EMBO Mol Med. 2024. In press, doi: 10.1038/s44321-024-00048-8.

N. L. Fogarty, T. Johnson, B. Kwok, A. Lin, T. K. Tsinman, X. Jiang, E. Koyama, L. Han, J. R. Baxter, R. L. Mauck, and N. A. Dyment. Reduction in post-natal weight-bearing does not alter the trajectory of murine meniscus growth and maturation. J. Orthop. Res. 2024. In press, doi: doi: 10.1002/jor.25711.

Z. Tian, F. S. Shofer, M. Fan, A. Z. Sandroni, L. Yao, L. Han, L. Qin, M. Enomoto-Iwamoto, and Y. Zhang. ADAM8 inactivation retards intervertebral disc degeneration in mice. Genes Dis. 2024. 11: 101059.

S. Ali Akbari Ghavimi, M. R. Aronson, D. D. Ghaderi, R. M. Friedman, N. Patel, T. Giordano, R. C. Borek, C. M. Devine, L. Han, I. N. Jacobs, and R. Gottardi. Modulated fibrosis and mechanotransduction of laryngeal fibroblast by SB525334 in pediatric subglottic stenosis. Laryngoscope 2024. 134: 287-296.

M. Petrovic, E. R. Kahle, L. Han, and M. S. Marcolongo. Biomimetic proteoglycans as a tool to engineer the structure and mechanics of porcine bioprosthetic heart valves. J. Biomed. Mater. Res. B Appl. Biomater. 2024. 112: e35336.

B. Kwok, P. Chandrasekaran, C. Wang, L. He, R. L. Mauck, N. A. Dyment, E. Koyama, and L. Han. Rapid specialization and stiffening of the primitive matrix in developing articular cartilage and meniscus. Acta Biomater. 2023. 168: 235-251.

C. W. Chikelu, M. Berns, D. Conover, R. Habas, L. Han, R. M. Street, and C. L. Schauer. Collagen nanoyarns: hierarchical three-dimensional biomaterial constructs. Biomacromolecules 2023. 24: 1155-1163.

V. G. Muir, S. Weintraub, A. P. Dhand, H. Fallahi, L. Han, and J. A. Burdick. Influence of microgel and interstitial matrix compositions on granular hydrogel composite properties. Adv. Sci. 2023. 10:2206117.

L. Han, D. Dean. Probing biological systems with mechanical microscopy. Prog. Biophys. Mol. Biol. 2022.176: 1-2 (Editorial).

E. R. Kahle, N. Patel, H. B. Sreenivasappa, M. S. Marcolongo, and L. Han. Targeting cell-matrix interface mechanobiology by integrating AFM with fluorescence imaging. Prog. Biophys. Mol. Biol. 2022. 176: 67-81.

W. Li, Y. Zhou, L. Han, L. Wang, and X. L. Lu. Calcium signaling of primary chondrocytes and ATDC5 chondrogenic cells under osmotic stress and mechanical stimulation. J. Biomech. 2022. 145: 111388.

M. Fan, C. Wang, B. Kwok, E. R. Kahle, L. He, X. L. Lu, R. L. Mauck, and L. Han. Impacts of aging on murine cartilage biomechanics and chondrocyte in situ calcium signaling. J. Biomech. 2022. 144: 111336.

L. Han. Drug delivery carriers can alter cartilage biomechanics. Biophys. J. 2022. 121: 3303-3304 (Commentary).

A. Porter, L. Wang, L. Han, and X. L. Lu. Bio-orthogonal click chemistry methods to evaluate the metabolism of inflammatory challenged cartilage after traumatic overloading. ACS Biomater. Sci. Eng. 2022. 8: 2564-2573.

Y. Wei, X. Ma, H. Sun, T. Gui, L. Yao, L. Zhong, W. Wu, B. Han, L. Han, F. Beier, M. Enomoto-Iwamoto, J. Ahn, and L. Qin. EGFR signaling is required for maintaining adult cartilage homeostasis and attenuating osteoarthritis progression. J. Bone Miner. Res. 2022. 37: 1012-1023.

D. Rux, K. Helbig, B. Han, C. Cortese, E. Koyama, L. Han, and M. Pacifici. Primary cilia direct murine articular cartilage tidemark patterning through Hedgehog signaling and ambulatory load. J. Bone Miner. Res. 2022. 37: 1097-1116.

E. R. Kahle, B. Han, P. Chandrasekaran, E. R. Phillips, M. K. Mulcahey, X. L. Lu, M. S. Marcolongo, and L. Han. Molecular engineering of pericellular microniche via biomimetic proteoglycans modulates cell mechanobiology. ACS Nano 2022. 16: 1220-1230.

P. Chandrasekaran, B. Kwok, B. Han, S. M. Adams, C. Wang, D. R. Chery, R. L. Mauck, N. A. Dyment, X. L. Lu, D. B. Frank, E. Koyama, D. E. Birk, and L. Han. Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: a fibrous-hyaline hybrid. Matrix Biol. 2021. 102: 1-19.

T. K. Tsinman, X. Jiang, L. Han, E. Koyama, R. L. Mauck, and N. A. Dyment. Intrinsic and growth-mediated cell and matrix specialization during meniscus tissue assembly. FASEB J. 2021. 35: e21779.

Y. Wei, H. Sun, T. Gui, L. Yao, L. Zhang, W. Yu, S.-J. Heo, L. Han, X. S. Liu, Y. Zhang, E. Koyama, F. Long, R. L. Mauck, J. Ahn, and L. Qin. The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair. eLife 2021. 10: e62917.

Z. Jia, M. C. Fernandes, Z. Deng, T. Yang, Q. Zhang, A. Lethbridge, J. Yin, J.-H. Lee, L. Han, J. C. Weaver, K. Bertoldi, J. Aizenberg, M. Kolle, P. Vukusic, and L. Li. Microstructural design for mechanical-optical multifunctionality in the exoskeleton of flower beetle Torynorrhina flammea. Proc. Natl. Acad. Sci. USA 2021. 118: e2101017118.

B. Han^Δ, Q. Li^Δ, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, and L. Han. Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis. Osteoarthr. Cartil. 2021. 29: 1181-1192. (^Δ: equal contribution)

Y. Wei, L. Luo, T. Gui, F. Yu, L. Yan, L. Yao, L. Zhong, W. Yu, B. Han, J. M. Patel, J. F. Liu, F. Beier, L. S. Levin, C. Nelson, Z. Shao, L. Han, R. L. Mauck, A. Tsourkas, J. Ahn, Z. Cheng, and L. Qin. Targeting cartilage EGFR pathway for osteoarthritis treatment. Sci. Transl. Med. 2021. 13: eabb3946.

C. E. Witherel, K. Sao, B. K. Brisson, B. Han, S. W. Volk, R. J. Petrie, L. Han, and K. L. Spiller. Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages. Biomaterials 2021. 269: 120667.

D. R. Chery, B. Han, Y. Zhou, C. Wang, S. M. Adams, P. Chandrasekaran, B. Kwok, S.-J. Heo, M. Enomoto-Iwamoto, X. L. Lu, D. Kong, R. V. Iozzo, D. E. Birk, R. L. Mauck, and L. Han. Decorin regulates cartilage pericellular matrix micromechanobiology. Matrix Biol. 2021. 96: 1-17.

B. G. Ashinsky, S. E. Gullbrand, C. Wang, E. D. Bonnevie, L. Han, R. L. Mauck, and H. E. Smith. Degeneration alters structure-function relationships at multiple length-scales and across interfaces in human intervertebral discs. J. Anat. 2021. 238: 986-998.

T. Fukui, J. H. N. Yik, B. Doyran, J. Davis, A. K. Haudenschild, E. E. Adampoulos, L. Han, and D. R. Haudenschild. Bromodomain-containing-protein-4 and cyclin-dependent-kinase-9 inhibitors synergistically reduce the severity of murine post-traumatic osteoarthritis. Osteoarthr. Cartil. 2021. 29: 68-77.

D. Chen, L. R. Smith, G. Khandekar, P. Patel, C. K. Yu, K. Zhang, C. S. Chen, L. Han, and R. G. Wells. Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization. Sci. Rep. 2020. 10: 19065.

C. Cui, D.-O. Kim, P. Min, B. Han, L. Han, Y. Sun, and L.-H. Han. 4-D printing of self-folding and cell-encapsulating 3-D microstructures as scaffolds for tissue-engineering applications. Biofabrication 2020. 12: 045018.

B. G. Ashinsky, S. E. Gullbrand, E. D. Bonnevie, C. Wang, D. H. Kim, L. Han, R. L. Mauck, and H. E. Smith. Sacrificial fibers improve matrix distribution and micromechanical properties in a tissue-engineered intervertebral disc. Acta Biomater. 2020. 111: 232-241.

D. R. Chery, B. Han, Q. Li, Y. Zhou, S.-J. Heo, B. Kwok, P. Chandrasekaran, C. Wang, L. Qin, X. L. Lu, D. Kong, M. Enomoto-Iwamoto, R. L. Mauck, and L. Han. Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis. Acta Biomater. 2020. 111: 267-278.

C. Loebel, M. Y. Kwon, C. Wang, L. Han, R. L. Mauck, and J. A. Burdick. Metabolic labeling to probe the spatiotemporal accumulation of matrix at the chondrocyte-hydrogel interface. Adv. Funct. Mater. 2020. 30: 1909802.
X. Li, S. Yang, L. Han, K. Mao, and S. Yang. Ciliary IFT80 is essential for intervertebral disc development and maintenance. FASEB J. 2020. 34: 6741-6756.
B. G. Ashinsky, E. D. Bonnevie, S. A. Mandalapu, S. Pickup, C. Wang, L. Han, R. L. Mauck, H. E. Smith, and S. E. Gullbrand. Intervertebral disc degeneration is associated with aberrant endplate remodeling and reduced small molecule transport. J. Bone Miner. Res. 2020. 35: 1572-1581.
Q. Li, B. Han, C. Wang, W. Tong, Y. Wei, W.-J. Tseng, L.-H. Han, X. S. Liu, M. Enomoto-Iwamoto, R. L. Mauck, L. Qin, R. V. Iozzo, D. E. Birk, and L. Han. Mediation of cartilage matrix degeneration and fibrillation by decorin in post-traumatic osteoarthritis. Arthritis Rheumatol. 2020. 72: 1266-1277.

L. Liao, S. Zhang, L. Zhao, X. Chang, L. Han, J. Huang, and D. Chen. Acute synovitis after trauma precedes and is associated with osteoarthritis onset and progression. Int. J. Biol. Sci. 2020. 16: 970-980.
J. Lim, X. Li, X. Yuan, S. Yang, L. Han, and S. Yang. Primary cilia control cell alignment and patterning in bone development via ceramide-PKCζ-β-catenin signaling. Commun. Biol. 2020. 3: 45.

C. Wang, B. K. Brisson, M. Terajima, Q. Li, K. Hoxha, B. Han, A. M. Goldberg, X. S. Liu, M. S. Marcolongo, M. Enomoto-Iwamoto, M. Yamauchi, S. W. Volk, and L. Han. Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus. Matrix Biol. 2020. 85-86: 47-67.

B. Han, Q. Li, C. Wang, P. Patel, S. M. Adams, B. Doyran, H. T. Nia, R. Oftadeh, S. Zhou, C. Y. Li, X. S. Liu, X. L. Lu, M. Enomoto-Iwamoto, L. Qin, R. L. Mauck, R. V. Iozzo, D. E. Birk, and L. Han. Decorin regulates the aggrecan network integrity and biomechanical functions of cartilage extracellular matrix. ACS Nano 2019. 13: 11320-11333.

B. G. Ashinsky, S. E. Gullbrand, E. D. Bonnevie, S. A. Mandalapu, C. Wang, D. M. Elliot, L. Han, R. L. Mauck, and H. E. Smith. Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model. Osteoarthr. Cartil. 2019. 27: 1860-1869.

W. Pei, J. Chen, C. Wang, S. Qiu, J. Zeng, M. Gao, B. Zhou, D. Li, M. S. Sacks, L. Han, H. Shan, W. Hu, Y. Feng, and G. Zhou. Regional biomechanical imaging of liver cancer cells. J. Cancer 2019. 10: 4481-4487.

M. Y. Kwon, C. Wang, J. H. Galarraga, E. Pure, L. Han, and J. A. Burdick. Influence of hyaluronic acid modification on CD44 binding towards the design of hydrogel biomaterials. Biomaterials 2019. 222: 119451.

A. Steplewski, J. Fertala, R. Tomlinson, K. Hoxha, L. Han, O. Thakar, J. Klein, J. Abboud, and A. Fertala. The impact of cholesterol deposits on the fibrillar architecture of the Achilles tendon in a rabbit model of hypercholesterolemia. J. Orthop. Surg. Res. 2019. 14: 172.

M. Terajima, Y. Taga, W. A. Cabral, Y. Liu, M. Nagasawa, N. Sumida, Y. Kayashima, P. Chandrasekaran, L. Han, N. Maeda, I. Perdivara, S. Hattori, J. C. Marini, and M. Yamauchi. Cyclophilin B control of lysine post-translational modifications of skin type I collagen. PLoS Genet. 2019. 15: e1008196.

M. Wang, C. Cui, M. M. Ibrahim, B. Han, Q. Li, M. Pacifici, J. T. R. Lawrence, L. Han, and L.-H. Han. Regulating mechanotransduction in three-dimensions using sub-cellular scale, crosslinkable fibers of controlled diameter, stiffness and alignment. Adv. Funct. Mater. 2019. 29: 1808697.

Z. Fan, J. Deng, P. Y. Li, D. R. Chery, Y. Su, P. Zhu, T. Kambayashi, E. P. Blankenhorn, L. Han, and H. Cheng. A new class of biological materials: Cell membrane-derived hydrogel scaffolds. Biomaterials 2019. 197: 244-254.

M. Lv, Y. Zhou, S. Polson, L. Wan, L. Han, M.-Q. Wang, L. Wang, and X. L. Lu. Identification of chondrocyte genes and signaling pathways in response to acute joint inflammation. Sci. Rep. 2019. 9: 93.

R. Malik, T. Luong, X. Cao, B. Han, N. Shah, J. Franco-Barraza, L. Han, V. B. Shenoy, P. I. Lelkes, and E. Cukierman. Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2. Matrix Biol. 2019. 81: 50-69.

T. Zhou, B. Han, H. Qi, Q. Pan, D. M. Smith, L. Han, and C. Y. Li. Velcro-mimicking surface based on polymer loop brushes. Nanoscale 2018. 10: 18269-18274

H. Qi, H. Zhou, Q. Tang, J. Y. Lee, Z. Fan, S. Kim, M. Staub, T. Zhou, S. Mei, L. Han, D. J. Pochan, H. Cheng, W. Hu, and C. Y. Li. Block copolymer crystalsomes with ultrathin shell to extend blood circulation time. Nat. Commun. 2018. 9: 3005.

S. Zhou, C. Hu, G. Zhao, T. Jin, S. Sheen, L. Han, L. Liu, and K. L. Yam. Novel generation systems of gaseous chlorine dioxide for Salmonella inactivation on fresh tomato. Food Control 2018. 92: 479-487.

K. Prudnikova, S. E. Lightfoot Vidal, S. Sarkar, T. Yu, R. W. Yucha, N. Ganesh, L. S. Penn, L. Han, C. L. Schauer, E. J. Vresilovic, and M. S. Marcolongo. Aggrecan-like biomimetic proteoglycans (BPGs) composed of natural chondroitin sulfate bristles grafted onto poly(acrylic acid) core for molecular engineering of the extracellular matrix. Acta Biomater. 2018. 75: 93-104.

R. M. Street, T. Huseynova, X. Xu, P. Chandrasekaran, L. Han, W. Y. Shih, W.-H. Shih, and C. L. Schauer. Variable piezoelectricity of electrospun chitin. Carbonhydr. Polym. 2018. 195: 218-224.

L. W. Gamer, S. Pregizer, J. Gamer, M. Fergenson, A. Ionescu, Q. Li, L. Han, and V. Rosen. The role of Bmp2 in the maturation and maintenance of the murine knee joint. J. Bone Miner. Res. 2018. 33: 1708-1717.

Q. Li, C. Wang, B. Han, F. Qu, H. Qi, C. Y. Li, R. L. Mauck, and L. Han. Impacts of maturation on the micromechanics of the meniscus extracellular matrix. J. Biomech. 2018. 72: 252-257.

B. R. Freedman, A. B. Rodriguez, C. D. Hillin, S. N. Weiss, B. Han, L. Han, and L. J. Soslowsky. Tendon healing affects the multiscale mechanical, structural, and compositional response of tendon to quasi-static tensile loading. J. R. Soc. Interface 2018. 15: 20170880.

F. Qu, Q. Li, X. Wang, X. Cao, M. Zgonis, J. Esterhai, V. B. Shenoy, L. Han, and R. L. Mauck. Maturation state and matrix microstructure regulate interstitial cell migration in dense connective tissues. Sci. Rep. 2018. 8: 3295.

S. L. Vega, M. Y. Kwon, K. H. Song, C. Wang, R. L. Mauck, L. Han, and J. A. Burdick. Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments. Nat. Commun. 2018. 9: 164.

H. Jia, X. Ma, Y. Wei, W. Tong, R. J. Tower, A. Chandra, L. Wang, Z. Sun, Z. Yuan, F. Badar, K. Zhang, W.-J. Tseng, I. Kramer, M. Kneissel, Y. Xia, X. S. Liu, J. H.-C. Wang, L. Han, M. Enomoto-Iwamoto, and L. Qin. Loading-induced reduction in Sclerostin as a mechanism of subchondral bone plate sclerosis in mouse knee joints during late-stage osteoarthritis. Arthritis Rheumatol. 2018. 70: 230-241.

M. Lv, Y. Zhou, X. Chen, L. Han, L. Wang, and X. L. Lu. Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading: roles of calcium sources and cell membrane ion channels. J. Orthop. Res. 2018. 36: 730-738.

B. Han, T. Ma, J. H. Vergara, G. R. Palmese, J. Yin, D. Lee, and L. Han. Non-additive impacts of covalent cross-linking on the viscoelastic nanomechanics of ionic polyelectrolyte complexes. RSC Adv. 2017. 7: 53334-53345.

C. M. J. de Bakker, W.-J. Tseng, Y. Li, H. Zhao, A. R. Altman-Singles, Y. Jeong, J. Robberts, L. Han, D.-G. Kim, and X. S. Liu. Reproduction differentially affects trabecular bone depending on its mechanical versus metabolic role. J. Biomech. Eng. 2017. 139: 111006.

Y.-C. Yeh, E. A. Corbin, S. R. Caliari, L. Ouyang, S. L. Vega, R. Truitt, L. Han, K. B. Margulies, and J. A. Burdick. Mechanically dynamic PDMS substrates to investigate changing cell environments. Biomaterials 2017. 145: 23-32.

B. Han, H. T. Nia, C. Wang, P. Chandrasekaran, Q. Li, D. R. Chery, H. Li, A. J. Grodzinsky, and L. Han. AFM-nanomechanical test: an interdisciplinary tool that links the understanding of cartilage and meniscus biomechanics, osteoarthritis degeneration and tissue engineering. ACS Biomater. Sci. Eng. 2017. 3: 2033-2049.

G. Lin, D. Ge, Y. Tang, Y. Xia, G. Wu, L. Han, S. Yang, and J. Yin. Cuts guided deterministic buckling in arrays of soft parallel plates for multifunctionality. ACS Appl. Mater. Interfaces 2017. 9: 29345-29354.

G. Lin, P. Chandrasekaran, C. Lv, Q. Zhang, Y. Tang, L. Han, and J. Yin. Self-similar hierarchical wrinkles as a potential multifunctional smart window with simultaneously tunable transparency, structural color, and droplet transport. ACS Appl. Mater. Interfaces 2017. 9: 26510-26517.

S. Cranford, L. Han, C. Ortiz, and M. J. Buehler. Mutable polyelectrolyte tube arrays: mesoscale modeling and lateral force microscopy. Soft Matter 2017. 13: 5543-5557.

P. Chandrasekaran^Δ, B. Doyran^Δ, Q. Li, B. Han, T. E. Bechtold, E. Koyama, X. L. Lu, and L. Han. Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation. J. Biomech. 2017. 60: 134-141. (^Δ: equal contribution)

A. R. Altman-Singles, Y. Jeong, W.-J. Tseng, C. M. J. de Bakker, H. Zhao, C. Lott, J. Robberts, L. Qin, L. Han, D.-G. Kim, and X. S. Liu. Intermittent parathyroid hormone after prolonged alendronate treatment induces substantial new bone formation and increases bone tissue heterogeneity in ovariectomized rats. J. Bone Miner. Res. 2017. 32: 1703-1715.

K. Prudnikova, R. Yucha, P. Patel, A. Kriete, L. Han, L. Penn, and M. S. Marcolongo. Biomimetic proteoglycans mimic macromolecular architecture and water uptake of natural proteoglycans. Biomacromolecules 2017. 18: 1713-1723.

Q. Li, F. Qu, B. Han, C. Wang, H. Li, R. L. Mauck, and L. Han. Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix. Acta Biomater. 2017. 54: 356-366.

D. Chen, J. Shen, W. Zhao, T. Wang, L. Han, J. J. Hamilton, and H.-J. Im. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res. 2017. 5: 16044.

B. Doyran^Δ, W. Tong^Δ, Q. Li, H. Jia, X. Zhang, C. Chen, M. Enomoto-Iwamoto, X. L. Lu, L. Qin, and L. Han. Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis. Osteoarthr. Cartil. 2017. 25: 108-117. (^Δ: equal contribution)

H. Jia, X. Ma, W. Tong, B. Doyran, Z. Sun, Z. Yang, X. Zhang, J. Wang, L. Han, M. Enomoto-Iwamoto, and L. Qin. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis progression. Proc. Natl. Acad. Sci. USA 2016. 113: 14360-14365.

C. B. Rodell, C. B. Highley, M. H. Chen, N. N. Dusaj, C. Wang, L. Han, and J. A. Burdick. Evolution of hierarchical porous structures in supramolecular guest-host hydrogels. Soft Matter 2016. 12: 7839-7847.

A. Goyal, M. A. Gubbiotti, D. R. Chery, L. Han, and R. V. Iozzo. Endorepellin-evoked autophagy contributes to angiostasis. J. Biol. Chem. 2016. 37: 19245-19256.

M. E. Candela, C. Wang, A. T. Gunawardna, K. Zhang, L. Cantley, Y. Usami, N. Francois, A. van der Flier, R. O. Hynes, Y. Zhang, L. Qin, L. Han, and M. Enomoto-Iwamoto. Alpha 5 integrin mediates osteoarthritic changes in mouse knee joints. PLoS One 2016. 11: e0156783.

T. Zhou, H. Qi, L. Han, D. Barbash, and C. Y. Li. Towards controlled polymer brushes via a self-assembly-assisted-grafting-to approach. Nat. Commun. 2016. 7: 11119.

W. Wang, H. Qi, T. Zhou, S. Mei, L. Han, T. Higuchi, H. Jinnai, and C. Y. Li. Highly robust crystalsome via directed polymer crystallization at curved liquid/liquid interface. Nat. Commun. 2016. 7: 10599.

P. Shi, E.-Y. Chen, G. Cs-Szabo, A. Chee, C. Tanoury, L. Qin, L. Han, S. An, H. An, and Y. Zhang. Biglycan inhibits capsaicin-induced substance P release by cultured dorsal root ganglion neurons. Am. J. Phys. Med. Rehabil. 2016. 95: 656-662.

B. K. Connizzo, L. Han, D. E. Birk, and L. J. Soslowsky. Collagen V-heterozygous and -null supraspinatus tendons exhibit altered dynamic mechanical behaviour at multiple hierarchical scales. Interface Focus 2016. 6: 20150043.

B. Han, D. R. Chery, J. Yin, X. L. Lu, D. Lee, and L. Han. Nanomechanics of layer-by-layer polyelectrolyte complexes: a manifestation of ionic cross-links and fixed charges. Soft Matter 2016. 12: 1158-1169.

Y. Tang, G. Lin, L. Han, S. Qiu, S. Yang, and J. Yin. Engineering hierarchical cuts for extremely soft, high strength, and reconfigurable auxetic metamaterials. Adv. Mater. 2015. 27: 7181-7190.

Z. Zhang, Q. Li, L. Han, and Y. Zhong. Layer-by-layer films assembled from natural polymers for sustained release of neurotrophin. Biomed. Mater. 2015. 10: 055006.

L. Ruggiero, B. K. Zimmerman, M. Park, L. Han, L. Wang, D. L. Burris, and X. L. Lu. Roles of fibrous superficial zone in the mechanical behavior of TMJ condyle cartilage. Ann. Biomed. Eng. 2015. 11: 2652-2662.

Q. Li, B. Doyran, L. W. Gamer, X. L. Lu, L. Qin, C. Ortiz, A. J. Grodzinsky, V. Rosen, and L. Han. Biomechanical properties of murine meniscus surface via AFM-based nanoindentation. J. Biomech. 2015. 48: 1364-1370.

H. T. Nia, L. Han, I. S. Bozchalooi, P. Roughley, K. Youcef-Toumi, A. J. Grodzinsky, and C. Ortiz. Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties. ACS Nano 2015. 9: 2614-2625.

B. Lee^Δ, L. Han^Δ, E. H. Frank, A. J. Grodzinsky, and C. Ortiz. Dynamic nanomechanics of individual bone marrow stromal cells and cell-matrix composites during chondrogenic differentiation. J. Biomech. 2015. 48: 171-175. (^Δ: equal contribution)
B. K. Connizzo, J. J. Sarver, L. Han, and L. J. Soslowsky. In situ fibril stretch and sliding is location-dependent in mouse supraspinatus tendons. J. Biomech. 2014. 47: 3794-3798.

M. A. Batista, H. T. Nia, P. Önnerfjord, K. A. Cox, C. Ortiz, A. J. Grodzinsky, D. Heinegård, and L. Han. Nanomechanical phenotype of chondroadherin-null articular cartilage. Matrix Biol. 2014. 38: 84-90.

M. K. Saums, W. Wang, B. Han, L. Madhavan, L. Han, D. Lee, and R. G. Wells. Mechanically- and chemically-tunable cell culture system to study myofibroblast phenotype. Langmuir 2014. 30: 5481-5487.

F. P. Rojas, M. A. Batista, C. A. Lindburg, D. Dean, A. J. Grodzinsky, C. Ortiz, and L. Han. Molecular adhesion between cartilage extracellular matrix macromolecules. Biomacromolecules 2014. 15: 772-780.

C. A. Rock, L. Han, and T. C. Doehring. Complex fiber and membrane morphologies of the whole porcine aortic valve. PLoS One 2014. 9: e86087.

H. T. Nia, I. S. Bozchalooi, Y. Li, L. Han, H.-H. Hung, E. H. Frank, K. Youcef-Toumi, C. Ortiz, and A. J. Grodzinsky. High bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys. J. 2013. 104: 1529-1537.

H.-Y. Lee^Δ, L. Han^Δ, P. J. Roughley, A. J. Grodzinsky, and C. Ortiz. Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. J. Struct. Biol. 2013. 181: 264-273. (^Δ: equal contribution)

L. Han, J. Yin, L. Wang, K.-K. Chia, R. E. Cohen, M. F. Rubner, C. Ortiz, and M. C. Boyce. Tunable stimulus-responsive friction mechanisms of polyelectrolyte films and tube forests. Soft Matter 2012. 8: 8642-8650.

S. Y. Wong, L. Han, K. Timachova, J. Veselinovic, M. H. Hyder, C. Ortiz, A. M. Klibanov, and P. T. Hammond. Drastically lowered protein adsorption on microbicidal hydrophilic/hydrophobic polyelectrolyte multilayers. Biomacromolecules 2012. 13: 719-726.

L. Han, L. Wang, K.-K. Chia, R. E. Cohen, M. F. Rubner, M. C. Boyce, and C. Ortiz. Geometrically controlled mechanically responsive polyelectrolyte tube arrays. Adv. Mater. 2011. 23: 4667-4673.

H. T. Nia, L. Han, Y. Li, C. Ortiz, and A. J. Grodzinsky. Poroelasticity of cartilage at the nanoscale. Biophys. J. 2011. 101: 2304-2313.

L. Han, L. Wang, J. Song, M. C. Boyce, and C. Ortiz. Direct quantification of the mechanical anisotropy and fracture of an individual exoskeleton layer via uniaxial compression of micropillars. Nano Lett. 2011. 11: 3868-3874.

L. Han, A. J. Grodzinsky, and C. Ortiz. Nanomechanics of the cartilage extracellular matrix. Annu. Rev. Mater. Res. 2011. 41: 133-168.

L. Han, E. H. Frank, J. J. Greene, H.-Y. Lee, H. K. Hung, A. J. Grodzinsky, and C. Ortiz. Time-dependent nanomechanics of cartilage. Biophys. J. 2011. 100: 1846-1854.

B. Lee, L. Han, E. H. Frank, S. Chubinskaya, C. Ortiz, and A. J. Grodzinsky. Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes. J. Biomech. 2010. 43: 469-476.

K. Tai, G. Pelled, D. Sheyn, A. Bershteyn, L. Han, I. Kallai, Y. Zilberman, C. Ortiz, and D. Gazit. Nanobiomechanics of repair bone regenerated by genetically modified mesenchymal stem cells. Tissue Eng. A 2008. 14: 1709-1720.

L. Han, D. Dean, L. A. Daher, A. J. Grodzinsky, and C. Ortiz. Cartilage aggrecan can undergo self-adhesion. Biophys. J. 2008. 95: 4862-4870.

L. Han, D. Dean, P. Mao, C. Ortiz, and A. J. Grodzinsky. Nanoscale shear deformation mechanisms of opposing aggrecan macromolecules. Biophys. J. 2007. 93: L23-L25.

L. Han, D. Dean, C. Ortiz, and A. J. Grodzinsky. Lateral nanomechanics of cartilage aggrecan macromolecules. Biophys. J. 2007. 92: 1384-1398.

M. Ye, D. Zhang, L. Han, J. Tejeda, and C. Ortiz. Synthesis, preparation and conformation of stimulus-responsive end-grafted poly(methacrylic acid-g-ethylene glycol) layers. Soft Matter 2006. 2: 243-256.

D. Dean, L. Han, A. J. Grodzinsky, and C. Ortiz. Compressive nanomechanics of opposing aggrecan macromolecules. J. Biomech. 2006. 39: 2555-2565.

D. Dean, L. Han, C. Ortiz, and A. J. Grodzinsky. Nanoscale conformation and compressibility of cartilage aggrecan using microcontact printing and atomic force microscopy. Macromolecules 2005. 38: 4047-4049.

S. M. Zhang, F. Z. Cui, S. S. Liao, Y. Zhu, and L. Han. Synthesis and biocompatibility of porous nanohydroxyapatite/collagen/alginate composite. J. Mater. Sci. Mater. Med. 2003. 14: 641-645.

Publications

Phone Number

Email Address

Location