NanoBiomechanics Lab

Overview

Welcome to the NanoBiomechanics Laboratory in the School of Biomedical Engineering, Science and Health Systems at Drexel University.

Our research aims to tackle the interdisciplinary challenges in the development, regeneration and degeneration of biological tissue extracellular matrix (ECM). We integrate novel approaches in nanotechnology, biomaterials, biomechanics, matrix biology and gene therapy, with a focus in three ECM biomolecules:

Aggrecan

A “bottle brush” - like large proteoglycan that is key to the compressive and energy dissipative biomechanical functions of compression-bearing tissues (cartilage, meniscus, nucleus pulposus).

Decorin

A small leucine-rich proteoglycan (SLRP) that plays crucial structural roles in regulating matrix assembly and mediating growth factor signaling.

Type V collagen

A regulatory fibril-forming collagen that mediates the initial assembly of collagen I fibers in embryonic development and tissue repair.

Overview

Aggrecan

Decorin

Type V collagen

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